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Orexigen Therapeutics, Spectrum Pharmaceuticals and PetMed Express lead small-cap volume in pre-market

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Orexigen Therapeutics Inc. (Nasdaq:OREX), Spectrum Pharmaceuticals Inc. (Nasdaq:SPPI) and PetMed Express Inc. (Nasdaq:PETS) are among the most actively traded companies in Monday's trading among companies with market capitalizations under $1 billion.

Also included among the results: Infinera Corp. (Nasdaq:INFN), CardioNet Inc. (Nasdaq:BEAT), ClickSoftware Technologies Ltd. (Nasdaq:CKSW), China Housing & Land Development Inc. (Nasdaq:CHLN), Fuqi International Inc. (Nasdaq:FUQI) and BioDelivery Sciences International Inc. (Nasdaq:BDSI).

Here are the biggest percentage losers among small caps:

    Price at 9:08 ET Change % Change Volume Year High Year Low
OREX OREXIGEN THERAPEUTICS INC   7.19     +1.50     +26.4%     382.5k     12.28     1.55  
SPPI SPECTRUM PHARMACEUTICALS INC   6.20     +0.65     +11.7%     64.5k     8.15     0.55  
PETS PETMED EXPRESS INC   17.90     +1.25     +7.5%     39.9k     19.03     12.92  
INFN INFINERA CORPORATION   7.60     -1.40     -15.6%     28.7k     11.88     5.69  
BEAT CARDIONET INC   6.48     +0.23     +3.7%     21.7k     35.89     5.60  
CKSW CLICKSOFTWARE TECHNOLOGIES L   7.12     +0.09     +1.3%     19.0k     7.18     1.80  
CHLN CHINA HOUSING & LAND DEV INC   5.90     +0.40     +7.3%     17.7k     6.15     0.75  
FUQI FUQI INTERNATIONAL INC   20.00     +0.16     +0.8%     14.8k     21.98     3.31  
BDSI BIODELIVERY SCIENCES INTL IN   5.75     -0.09     -1.5%     14.4k     8.29     1.93  
BCRX BIOCRYST PHARMACEUTICALS   5.95     +0.00     +0.1%     11.3k     6.43     0.85