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Pre-market: PharmaNet Development Group, Salix Pharmaceuticals and Shutterfly lead small-cap volume

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PharmaNet Development Group Inc. (Nasdaq:PDGI), Salix Pharmaceuticals, Ltd. (Nasdaq:SLXP) and Shutterfly, Inc. (Nasdaq:SFLY) are among the most actively traded companies in Thursday's pre-market trading among those with market capitalizations under $750 million.

Jos. A. Bank Clothiers, Inc. (Nasdaq:JOSB), CV Therapeutics, Inc. (Nasdaq:CVTX) and InterMune, Inc. (Nasdaq:ITMN) are also among the most actively traded small-cap companies in pre-market trading.

Here are the most actively traded small-cap companies in Thursday's pre-market trading:

    Price at 9:10 ET Change % Change Volume Year High Year Low
 PDGI  PHARMANET DEV GROUP INC   16.57     -7.29     -30.6%     144.1k     43.05     23.29  
 SLXP  SALIX PHARMACEUTICALS INC   7.02     +0.00     +0.0%     74.6k     14.26     5.40  
 SFLY  SHUTTERFLY INC   13.50     -2.85     -17.4%     69.5k     37.00     13.43  
 JOSB  JOS A BANK CLOTHIERS INC   24.41     +0.00     +0.0%     67.3k     46.16     18.81  
 CVTX  CV THERAPEUTICS INC   9.15     +0.00     +0.0%     61.9k     13.74     5.41  
 ITMN  INTERMUNE INC   15.85     +0.00     +0.0%     59.8k     30.75     11.72  
 CADX  CADENCE PHARMACEUTICALS INC   6.56     +0.00     +0.0%     53.4k     16.07     4.84  
 IWOV  INTERWOVEN INC   11.26     +0.00     +0.0%     52.8k     15.92     10.40  
 HIBB  HIBBETT SPORTS INC   18.26     +0.00     +0.0%     46.7k     30.62     12.30  
 SCRX  SCIELE PHARMA INC   20.00     +0.73     +3.8%     44.4k     28.83     17.77